In the year 1000 CE, an infant with difficulty nursing since birth is brought to Abul Qasim al-Zahrawi, who works in Cordoba, Andalusia (present-day Spain). The boy infant is the product of a normal term pregnancy. On physical examination the only abnormality is the lack of fusion between the lateral medial nasal prominence and the maxillary prominence. The cleft lip is repaired. There is no family history of birth defects, and the mother’s other two children are healthy with no apparent abnormalities. This clinical picture is most likely the result of which of the following conditions?<br><p>A Chromosomal anomaly </p><p>B Early amnion disruption </p><p>C Maternal malnutrition</p><p>D Multifactorial inheritance </p><p>E Single gene defect</p><p>F Teratogenicity</p><p> </p><p>公元1000年，一个自出生起就哺乳困难的婴儿被带到安达卢西亚（今西班牙）科尔多瓦工作的阿布·卡西姆·扎赫拉维（Abul Qasim al-Zahrawi）那里。男婴是正常足月妊娠的产物。体格检查时，唯一的异常是外侧内侧鼻突起和上颌突起之间缺乏融合。唇裂得到修复。没有出生缺陷的家族史，母亲的另外两个孩子健康，没有明显的异常。这种临床表现很可能是以下哪种情况的结果？</p><p><br></p><p>A 染色体异常</p><p>B 早期羊膜破裂</p><p>C 产妇营养不良</p><p>D 多因素遗传</p><p>E 单基因缺陷</p><p>F 致畸性</p>